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New aspects of developing a dry powder inhalation formulation applying the...
DRUG REGULATORY AFFAIRS INTERNATIONAL The current work outlines the application of an up-to-date and regulatory-based pharmaceutical quality management method, applied as a new development concept in...
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Mitiglinide
Mitiglinide MF C19H25NO3 MW 315.407 Da Mitiglinide (INN, trade name Glufast) is a drug for the treatment of type 2 diabetes.[1] Mitiglinide belongs to the meglitinide class of blood glucose-lowering...
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Novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8)
MF C22H20N4O2, MW 372.4 (S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide Applicants: TRUSTEES OF BOSTON UNIVERSITY DANA-FARBER CANCER INSTITUTE, INC....
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PF-04136309
PF 4136309 PF4136309; PF 4136309; PF-4136309; PF04136309; PF4136309; PF-04136309; INCB8761; INCB 8761; INCB-8761...
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CHIRAL INDIA 2016, 5th International Conference & Exhibition Nov 8-9 2016,...
India's only conference focusing on new chiral technologies for pharmaceutical fine chemicals. The event is a unique platform to learn about recent advances in chiral chemistry, technology and...
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Evofosfamide, эвофосфамид , إيفوفوسفاميد , 艾伏磷酰胺 ,
Evofosfamide, HAP-302 , TH-302, TH 302 эвофосфамид , إيفوفوسفاميد , 艾伏磷酰胺 , Molecular Formula C9H16Br2N5O4P Average mass 449.036 Da (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl...
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Continuous Flow Stereoselective Synthesis of (S)-Warfarin
Continuous Flow Stereoselective Synthesis of (S)-Warfarin The same catalytic packed-bed reactor was used for the preparation of (S)-warfarin 107 under continuous flow conditions (Scheme ).A solution...
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SNS-032, BMS-387032A potent and selective Cdk inhibitor
SNS 032, BMS-387032 N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide Cas 345627-80-7, MP 165-167° C M.Wt:380.53, Formula:C17H24N4O2S2 SNS 032, BMS-387032...
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Flow synthesis of Meclinertant
SR48692 (Meclinertant) Reminertant; SR 48692 CAS [146362-70-1] Molecular FormulaC32H31ClN4O5 Average mass587.065 SEE…...https://newdrugapprovals.org/2014/12/31/meclinertant-sr48692/...
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ALMOREXANT REVISITED
Almorexant; ACT-078573; (R)-2-((S)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide; Almorexant (INN, codenamed ACT-078573) is an orexin...
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1, 2-Bis(4-(4-4-nitrophenyl)piperazin-1-yl)ethanone for androgen sensitive...
1, 2-Bis(4-(4-4-nitrophenyl)piperazin-1-yl)ethanone Molecular Formula: C22H26N6O5 Molecular Weight: 454.47904 g/mol CAS 330633-91-5 CDRI-? For treatment of androgen sensitive prostatic disorders 1,...
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DDD 107498
DDD 107498, DDD 498 PATENT WO 2013153357, US2015045354 6-Fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide...
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PF-04745637
PF-04745637 cas 1917294-46-2 MW 509.00, MF C27 H32 Cl F3 N2 O2 Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]-...
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Ibipinabant Revisited
Ibipinabant cas 464213-10-3; UNII-O5CSC6WH1T; BMS-646256; SLV-319; Molecular Formula: C23H20Cl2N4O2S Molecular Weight: 487.4015 g/mol...
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Analytical Lifecycle: USP “Statistical Tools”, Analytical Target Profile and...
DRUG REGULATORY AFFAIRS INTERNATIONAL Analytical Lifecycle: USP <1210> “Statistical Tools”, Analytical Target Profile and Analytical Control Strategy The United States Pharmacopeia (USP) is...
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How to document a Product Transfer? Example templates!
DRUG REGULATORY AFFAIRS INTERNATIONAL All participants of the GMP training course “Product Transfer” will receive a special version of the Guideline Manager CD including documents and templates...
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ORM 10921
ORM 10921 UNII-D26C95A960; D26C95A960; ORM-12741; ORM12741; ORM 12741; ORM-10921; (1S,12bS)-1-(Methoxymethyl)-1-methyl-2,3,4,6,7,12b-hexahydro-1H-[1]benzofuro[2,3-a]quinolizine...
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(3S)-3-[(2-amino-5-methoxypyrimidin-4-yl)amino]heptan-1-ol for the treatment...
(3S)-3-[(2-amino-5-methoxypyrimidin-4-yl)amino]heptan-1-ol for the treatment of viral infections Molecular Formula: C12H22N4O2 Molecular Weight: 254.32868 g/mol To the use of pyrimidine derivatives in...
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JNJ 54166060
JNJ 54166060 JNJ-54166060; JNJ 54166060; JNJ54166060. (R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)methanone...
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