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Channel: DR ANTHONY MELVIN CRASTO Ph.D – New Drug Approvals
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FDA Warning Letter on Data Integrity

Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: The integrity of data is currently in the focus of international authorities In particular the US FDA issued serious violations in Warning...

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Raw Material Variation into QbD Risk Assessment

Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: Areas of discussion included how expectations for raw material control are evolving within changing regulatory and business paradigms...

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AXITINIB

Axitinib (AG013736; trade name Inlyta) is a small molecule tyrosine kinase inhibitor developed by Pfizer. It has been shown to significantly inhibit growth of breast cancer in animal (xenograft)...

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How flow chemistry can make processes greener.. Case study 1 Methylation with...

Originally posted on Green Chemistry International: How flow chemistry can make processes greener Case study 1 Methylation with DMC. Increasing reaction efficiency through access to a wider range of...

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Zydus Cadila Healthcare Ltd, WO 2015102017, lorcaserin

Processes for the preparation of lorcaserin Zydus Cadila Healthcare Ltd WO 2015102017, 09 July2015  Applicants: CADILA HEALTHCARE LIMITED [IN/IN]; Zydus Tower, Satellite Cross Roads Ahmedabad – 380...

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Fispemifene for hypogonadism

    Fispemifene, HM 101 Fispemifene; UNII-3VZ2833V08; cas 341524-89-8 Molecular Formula: C26H27ClO3 Molecular Weight: 422.94378 g/mol...

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What is SBM-TFC-039 an SGLT Inhibitor from Sirona Biochem !!

A new “flozin” seems to me appearing on the horizon in form of SBM-TFC-039 an SGLT Inhibitor from Sirona Biochem, picked up a list from WO 2012160218,  from TFChem…….see link , Sirona Biochem Announces...

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Toremifene

Toremifene 2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine...

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Verubecestat (MK-8931)

Verubecestat (MK-8931) Merck Alzheimer’s drugs Verubecestat (MK-8931) is an oral β- amyloid precursor protein cleaving enzyme (BACE1 or β-secretase enzyme) inhibitor, is currently in Phase III...

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Odalasvir

ACH-3102 , Odalasvir Odalasvir ACH-0143102; ACH-3102 CAS : 1415119-52-6 Dimethyl N, N ‘- (tricyclo [8.2.2.24,7] hexadeca-1 (12), 4,6, 10,13,15-hexaene-5,11-diylbis {1H-benzimidazole-5,2-diyl [(2S,...

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How flow chemistry can make processes greener…………Supercritical fluids

Safe, small scale access to supercritical fluids The ability to safely access high temperatures and pressures in flow reactors has implications not only on the rate of chemical reactions, but also on...

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TOFACITINIB 的合成, トファシチニブ, Тофацитиниб, توفاسيتين يب SPECTRAL VISIT

Tofacitinib Citrate, 的合成 托法替布,  トファシチニブクエン酸塩, Тофацитиниба Цитрат  3-{(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile citrate salt CAS :...

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POSACONAZOLE

…… Posaconazole  泊沙康唑 ,  بوساكونازول , Позаконазол Sch–56592...

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VORICONAZOLE SPECTRAL VISIT

.  VORICONAZOLE 1H NMR……… http://file.selleckchem.com/downloads/nmr/S144202-Voriconazole-HNMR-Selleck.pdf 1H NMR DMSO-d6, peak at 3.3 is HOD PIC FROM THE NET   m.p=134 1H-NMR (300 MHz, DMSO-d6) δ...

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RIVAROXABAN 利伐沙班 ريفاروكسابان Ривароксабан SPECTRAL VISIT

RIVAROXABAN 5-Chloro-N-{[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinophenyl]oxazolidin-5-yl]methyl} thiophene-2-carboxamide...

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New Drug Approvals blog fast approaching 8 lakh views ( 27/7/2015)

New Drug Approvals blog fast approaching 8 lakh views ( 27/7/2015) 799174 VIEWS IN 208 COUNTRIES  Filed under: Anthony crasto, BLOGS Tagged: Anthony crasto, BLOG, New drug approvals

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Ozanimod, RPC1063

  cas 1306760-87-1 Ozanimod, RPC1063 Receptos, Inc.  INNOVATOR IUPAC/Chemical name: (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile...

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DACLATASVIR, 达拉他韦 , Даклатасвир , داكلاتاسفير ,

  Daclatasvir BMS-790052,  EBP 883; BMS 790052 THERAPEUTIC CLAIM Treatment of hepatitis C   CHEMICAL NAMES 1. Carbamic acid, N,N’-[[1,1′-biphenyl]-4,4′-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-...

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ORGANIC SPECTROSCOPY INTERNATIONAL HAS 2 LAKH VIEWS

ORGANIC SPECTROSCOPY INTERNATIONAL HAS 2 LAKH VIEWS Read by one and all in academics and industry link is ……http://orgspectroscopyint.blogspot.in/ I get minimum 1000 hits in a day and all across the...

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Eisai’s lenvatinib 兰伐替尼 レンバチニブ gets FDA approval

  Lenvatinib Mesilate Eisai’s lenvatinib 兰伐替尼 レンバチニブ   see synthesis at...

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