IVACAFTOR
Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor
Article first published online: 3 NOV 2015
DOI: 10.1002/ejoc.201501048
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201501048/abstract
SUPPORTING INFO……….http://onlinelibrary.wiley.com/store/10.1002/ejoc.201501048/asset/supinfo/ejoc_201501048_sm_miscellaneous_information.pdf?v=1&s=2b5b6ac6456ec88f478c07a692e49254e7239f80
Abstract
A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop–Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.
REFERENCES
N. Vasudevan, Gorakhnath R. Jachak And D. Srinivasa Reddy, Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor, Eur. J. Org. Chem., , 0000 (2015), DOI:10.1002/ejoc.201501048. 
http://academic.ncl.res.in/publications/index/select-faculty/2015/ocd
Breaking and Making of Rings: A Method for the Preparation …
6 days ago – European Journal of Organic Chemistry … 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive …
European Journal of Organic Chemistry – Wiley Online Library
European Journal of Organic Chemistry ….. examples and is successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.
Breaking and making – Wiley Online Library
6 days ago – … for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor … European Journal of Organic Chemistry.
READ ABOUT DR SRINIVASA REDDY at…………
ONE ORGANIC CHEMIST ONE DAY BLOG……..LINK
Dr. Srinivasa Reddy of CSIR-NCL bags the
prestigious Shanti Swarup Bhatnagar Prize
AN INTRODUCTION
Ph.D., University of Hyderabad, 2000 (Advisor: Professor Goverdhan Mehta).
Post-doctoral with Profs. Sergey A. Kozmin(University of Chicago, USA) and Prof.
Jeffrey Aubé (University of Kansas, USA)
Experienced in leading drug discovery programs (Dr. Reddy’s & TATA Advinus – 7
years of pharma experience)
Acquired skills in designing novel small molecules and lead optimization
Experienced in planning and execution of total synthesis of biologically active
molecules with moderate complexity
One of the molecules is currently in human clinical trials.
Filed under: Uncategorized Tagged: CSIR-NCL, Ivacaftor, NCL, Srinivasa Reddy
