Table of Contents

• 1. Introduction
• 2. Criteria for Process Assessment
• • 2.1. Safety Issues2.1.1. Potential Safety Issues and Their Significance
• 2.1.2. Prediction and Assessment of Safety Issues
• 2.1.3. Options To Manage Safety Issues
• 2.1.4. Designing a Safer New Route
• • 2.2. Environmental Issues
• 2.2.1. Potential Environmental Issues and Their Significance
• 2.2.2. Prediction and Assessment of Environmental Issues
• 2.2.3. Options To Manage Environmental Issues
• 2.2.4. Designing a New “Greener” Route
• • 2.3. Legal Issues
• 2.3.1. Potential Legal Issues and Their Significance
• 2.3.2. Prediction and Assessment of Legal Issues Associated with Regulated Substances
• 2.3.3. Prediction and Assessment of Legal Issues Associated with Patent Infringement
• 2.3.4. Options To Manage Patent Issues
• 2.3.5. Designing a New Route with Freedom To Operate
• • 2.4. Economic Issues
• 2.4.1. Potential Economic Issues and Their Significance
• 2.4.2. Prediction and Assessment of Economic Issues
• 2.4.3. Options To Manage Economic Issues
• 2.4.4. Designing a Cost-Effective New Route
• • 2.5. Control Issues
• 2.5.1. Potential Control Issues and Their Significance
• 2.5.2. Prediction and Assessment of Control Issues
• 2.5.3. Options To Manage Control Issues
• 2.5.4. Designing a New Route with Adequate Control Measures
• • 2.6. Throughput Issues
• 2.6.1. Potential Throughput Issues and Their Significance
• 2.6.2. Prediction and Assessment of Throughput Issues
• 2.6.3. Options To Manage Throughput Issues
• 2.6.4. Designing a New Route with High Throughput
• 3. Interrelationships between Process Issues
• 4. Conclusions
• 5. Acknowledgments
• 6. References