Ataciguat

Ataciguat HMR-1766

5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide

C₂₁H₁₉Cl₂N₃O₆S₃

_{UNII-QP166M390Q;}

_{576.49306 g/mol}
A guanylate cyclase activator potentially for the treatment of aortic valve stenosis.

CAS No. 254877-67-3

Originator sanofi-aventis
Developer Mayo Clinic; National Center for Advancing Translational Sciences; Sanofi; sanofi-aventis
Class Anthranilic acids; Benzamides; Cardiovascular therapies; Chlorobenzenes; Morpholines; Small molecules; Sulfonamides; Thiophenes
Mechanism of Action Guanylate cyclase stimulants

30 Jun 2015 Mayo Clinic plans a phase II trial for Aortic valve stenosis in USA (NCT02481258)
29 Jan 2014 Phase-I clinical trials in Aortic valve stenosis in USA (PO)
01 Jan 2010 Discontinued – Phase-II for Peripheral arterial occlusive disorders in Austria, Canada, France, Germany, Italy, Poland, Portugal, Russia, South Africa and USA (PO) prior to 2010

synthesis…..coming

Patent

HMR-1766 (ataciguat sodium, see patent publication WO2000002851)

PATENT

Patent	Submitted	Granted
TRA COMBINATION THERAPIES [US2007238674]	2007-10-11
sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS [US2013035340]	2011-02-03	2013-02-07
SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS [US2013123354]	2013-01-08	2013-05-16
Novel combination [US2005059660]	2004-07-29	2005-03-17
SGC STIMULATORS OF SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION [US2014288079]	2014-03-18	2014-09-25

Patent	Submitted	Granted
novel use of activators and stimulators of soluble guanylate cyclase for the prevention or treatment of renal disorders [US2010016305]	2010-01-21
HETEROARYL-SUBSTITUTED PIPERIDINES [US8119663]	2009-12-10	2012-02-21
Use of soluble guanylate cyclase activators for the treatment of Raynaud’s Phenomenon [US2009215769]	2009-08-27
Use of Activators of Soluble Guanylate Cyclase for Promoting Wound Healing [US2009221573]	2009-09-03
Use of Suluble Guanylate Cyclase Acitvators for Treating Acute and Chronic Lung Diseases [US2009286781]	2009-11-19
Use of Activators of Soluble Guanylate Cyclase for Treating Reperfusion Damage [US2009298822]	2009-12-03
HETEROCYCLIC DERIVATIVE AND USE THEREOF [US2011028493]	2011-02-03
SUBSTITUTED PIPERIDINES [US8202862]	2010-12-02	2012-06-19
METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS [US2009022729]	2009-01-22
sGC STIMULATORS [US2014323448]	2014-04-29	2014-10-30